منابع مشابه
Anti-IL5 therapy for asthma and beyond
Airway inflammation is considered to be the primary component contributing to the heterogeneity and severity of airway disorders. Therapeutic efficacies of diverse novel biologics targeting the inflammatory pathways are under investigation. One such target is IL-5, a type-1 cytokine that is central to the initiation and sustenance of eosinophilic airway inflammation. Over the past decade, anti-...
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Omalizumab (anti-IgE ab) is a recombinant humanized monoclonal antibody (rhuMAb-E25) developed by immunizing mice with human IgE. Then, a monoclonal antibody was selected that recognizes IgE at the same site as the highaffinity receptor for IgE (FcεRI). Omalizumab is the only Mab to date that has been found to be effective and approved by both the FDA and European Medicines Agency (EMA) for the...
متن کاملAnti-interleukin-5 therapy and severe asthma.
Asthma is a chronic inflammatory disorder of the airways that leads to acute symptoms, exacerbations and sometimes, for a small part of the asthmatic population, fatal or near-fatal exacerbations. This as yet significant minority of individuals present with severe asthma and have persisting daily symptoms, and exacerbations despite compliance with high doses of inhaled steroids and additional t...
متن کاملAnti-inflammatory drugs in asthma therapy
29 Bronchial asthma is a chronic inflammatory disease characterized by reversible airways obstruction, airways inflammation and increased airways responsiveness to a variety of stimuli. Clinical and experimental studies have shown the contribution of the airways inflammation to clinical course and severity of asthma. Anti-inflammatory drugs are therefore of major importance in the treatment of ...
متن کاملAnti-interleukin-13 antibody therapy for asthma: one step closer.
C urrent guidelines for the treatment of asthma recommend inhaled corticosteroids for all patients with persistent asthma. Despite the increasing use of these drugs, asthma remains poorly controlled in a small subset of individuals who do not respond fully to existing therapies. The medical needs of these patients have prompted a search for new medications that inhibit specific molecular target...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2014
ISSN: 1939-4551
DOI: 10.1186/1939-4551-7-32